将编码人类胎儿tau(三重复型,MAPT)最短等位基因的cDNA,不包含N端插入,插入到mouse Hmgcr启动子区域、外显子1(非转录)和主要内含子1之后,构建在pHMG载体中。这个构建物通过微注射注入了(C57BL/6J x CBA)F2的受精卵。在成年动物的多个脑区域,通过 Western blot 方法检测到人类tau(MAPT)蛋白在神经细胞体和树突中。(来源:J:101993)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(C57BL/6J x CBA)F2
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插入
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1
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4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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