这个靶向构建包含4kb的mouse肌肉 creatine kinase(MCK)启动子序列,位于一段1.2kb的人类acyl-CoA:diacylglycerol acyltransferase 2(DGAT2) cDNA序列的上游,后面跟着2.2kb的人类生长激素微型基因(包含polyA信号)。这个转基因元件通过微注射注入C57BL/6NHsd的受精卵中,然后将转基因后代与C57BL/6NHsd杂交,最终建立了Founder line 10小鼠品系。(来源:J:129495)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6NHsd
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1
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
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Year
IF
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