这个转基因包含了小鼠Eda-A1亚型的编码区域,插入在TRE/PminCMV启动子和SV40polyA序列之间。tetracycline响应转录激活因子(tTA)与TRE结合,驱动转录。Eda的表达在添加doxycycline时受到抑制,而在doxycycline不存在时表达。Eda-A1亚型的受体是Edar(来源:J:86628)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6J
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插入
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3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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