这个转基因构建包含大鼠Bdnf的cDNA序列,起始密码子前插入了Kozak序列,由小鼠Camk2a启动子调控。SV40内含子和polyA序列被插入在Bdnf cDNA的3'端。免疫荧光染色(ISH)显示,Bdnf的过表达主要限制在前脑区域,包括全部新皮质、部分海马、杏仁核和纹状体。(来源:J:57645)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(C57BL/6 x DBA/2)F2
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插入
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1
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10

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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