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中文
Pax8-rtTA构建包含优化的rtTA2s-M2cDNA和SV40polyA序列，这些替换了小鼠Pax8序列的内源性起始翻译位点。rtTA2S*M2变异体通过在TetR域有5个氨基酸改变（S12G、E19G、A56P、D148E和H179R）以及一个合成优化的转录激活域，使其基础活性降低，对多西环素的敏感性增强，相较于野生型rtTA。 (来源：J:140925)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
