Exon 1被替换为一个由pgk-neo cassette环绕的loxP座标记的序列。 Western blot结果显示突变小脑、新皮质和海马区域没有检测到蛋白质(来源:J:120106, J:121256)。
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Exon 1 was replaced by a pgk-neo cassette flanked by loxP sites. Western blot confirmed absence of protein in mutant cerebellum, neocortex and hippocampus. (J:120106, J:121256)