将小鼠Lta基因与Ltb的跨膜域融合,并插入含有小鼠Igκ(κ链)启动子和增强子的载体中。生成的实验鼠带有该转基因的多个拷贝,通过κ轻链的增强子和启动子,它们表达出膜形式的淋巴毒素α(LTa)。LTa转基因在B淋巴细胞中特异性表达。(来源:J:73100)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(C57BL/6J x DBA/2J)F2
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插入
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2
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2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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