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中文
从2号外显子到4号外显子，以及5号外显子的部分区域被替换为带有IRES-eGFP和一个敲除的PGK-neo元件。随后，通过内源性Cre介导的重组，在体内移除了neo cassette。免疫组化和western blot结果显示，纯合子小鼠中蛋白质表达几乎完全丧失。杂合子中则未检测到GFP表达。（来源：J:119476）
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
