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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
转基因模型
Tg(NEFL-cre)50Msd
Alias:
NF-L-Cre
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基础信息
表型特征
文献报道
使用了2kb的人类启动子和3kb下游序列来驱动Cre在大脑和脊髓中的表达。通过构建了两条线(50号和13号),其中只有50号线显示出表达。通过与LacZ标记品系的杂交来检测转座子的插入,重组导致了神经元中LacZ的表达。(来源:J:77229)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
3702327
(129X1/SvJ x 129S1/Sv)F1-Kitl+
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4
Phenotypes
Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes
References Literature
Title
PMID
Journal
Year
IF
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