将1-13号外显子(19.2kb)替换为lacZ-neo载体,构建了一个无功能等位基因。通过Western blot检测MEFs在无IFN处理和有IFN处理下的蛋白质表达,确认了无蛋白产物产生。(来源:J:119392)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129 x C57BL/6)F1
Targeted
插入,基因内删除
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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