在小鼠胚胎干细胞中,通过同源重组在基因的5'端插入了-loxP序列,并在第3号启动子位置插入了含floxed neo的 cassette。随后,通过暂时的Cre表达,去除了所有floxed序列。 Western blot结果显示,纯合小鼠眼组织匀浆中未检测到蛋白表达。(来源:J:118293)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
基因内删除
--
1
7
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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