这个转基因包含了一个人源角蛋白14的2075bp启动子构建,驱动表达一个编码融合蛋白的cDNA,该蛋白由人类RAF1催化域的激活突变型(Y340D/Y341D)和人雌激素受体1的配体结合域通过羧基端相连。这种融合蛋白可以通过外用4-hydroxytamoxifen在表皮中激活。(来源:J:81660, J:118584, J:118585)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6
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插入
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1
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5

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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