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An EGFP reporter gene followed by a single loxP site was inserted into intron 1 in reverse transcriptional orientation to the gene. A neomycin selection gene followed by a single loxP site and a thymidine kinase promoter were inserted into intron 7. Tissue specific cre mediated recombination deletes exons 2-7 and brings the thymidine kinase promoter into proximity of the EGFP gene conditionally activating transcription and expression of the reporter. (J:69949)