这个等位基因是在Surf1tm2Zev通过Cre介导的Neomycin抗性 cassette切除后产生的。LoxP在第7外显子中残留,导致从cDNA下游第674个核苷酸位置开始的阅读框被打断,接着用TAA终止密码子替换编码N225的密码子。这种框架移位理论上会去掉81个羧基端的氨基酸,但 Western blot检测并未发现蛋白质。(来源:J:117871)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S7/SvEvBrd-Hprt1+
Targeted
插入
--
1
5
6

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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