设计了一个靶向载体,目标是去除基因的2号外显子、2号内含子、3号外显子和3号内含子,同时产生框架移位。载体包含一个含氨苄青霉素抗性基因和一种仅在睾丸特异表达的血管紧张素转换酶启动子,驱动Cre重组酶的表达。当这个含有的“floxed cassette”在通过雄性生殖系统时,会从定位点上剔除。(来源:J:117713)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S1
Targeted
插入,基因内删除
--
1
--
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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