在小鼠胚胎干细胞(Ptcra, pTalpha)基因的第一个外显子中插入了一个包含优化后的密码子、SV40polyadenylation信号和Frt引导的neo选择子的mini-gene。在体外通过转染法用flippase短暂去除neo。cre的表达在未成熟DP胸腺细胞和更成熟SP细胞中观察到。(来源:J:117041, J:197923)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入
--
1
--
8

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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