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在第3和13个内含子中引入了LoxP位点，以便通过Cre酶通过5到13号外显子的敲除。随后，作为可选择标记插入的neo cassette在与Cre敲除突变体(Tg(CMV-cre)1Cgn小鼠)杂交后被移除。通过Southern blot分析确认了基因组的改变。(来源：J:126551)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
