在第56个内含子中插入了loxP位点,随后是含氨苄青霉素抗性基因座,其周围有FRT序列,接着在第58个内含子中插入了第二个loxP位点。这样,SET域的61个氨基酸中的121个序列被loxP位点包裹。随后通过Cre介导的重组,去除了57-58号外显子,包括编码RYINHS模式的序列,该模式是SET域催化核心区域的一部分。(来源:J:116064)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129X1/SvJ
Targeted
基因内删除
--
1
4
7

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
Show/Hide columns
Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
微信
信息比对
科研助手
使用教程
回到顶部