这种突变在BALB/cHeA小鼠中被发现。Southern blot分析未检测到基因的任何缺失、插入或重排。然而,对棕色脂肪来源的RNA进行的Northern blot分析显示,转录本水平减少了50倍,并且这种转录本的大小发生了改变。 (Source: The mutation was detected in BALB/cHeA mice. Southern blot analysis failed to detect any deletions, insertions, or rearrangements of the gene. Northern blot analysis on RNA from brown fat revealed a 50-fold decrease in transcript abundance with an altered transcript size.)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count