在ENSMUST00000059287的第十外显子(10号外显子)中,我们设计了一种突变,将苯丙氨酸的密码子613(TTT)替换为天冬氨酸(GAT)(p.F613D)。随后,我们插入了一个由loxP序列引导的诺卡因抗性基因元件到第9号内含子内。之后,通过Cre介导的重组,去除了这个neo cassette。(来源:J:115873)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
核苷酸替换
--
1
3
6

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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