构建了一个靶向载体,通过将包含cre重组酶编码序列、核定位信号和由FRT座点 flank的PGK-neo基因的元件插入Slc6a4基因的5'UTR。在ES细胞中进行同源重组后,产生了表达cre重组酶的Slc6a4基因小鼠。检测结果显示cre重组酶在Raphe核中表达。随后通过Flp介导的重组,移除了FRT座点标记的neo cassette(来源:J:115426)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S1/Sv-Oca2+ Tyr+ Kitl+
Targeted
插入
--
1
2
65

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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