Tg(CAG-PRNP)1Ondr

The transgene comprises the coding sequence of the prion protein gene from the scimitar-horned oryx, Oryx dammah, under control of the "CAG promoter", which consists of the cytomegalovirus immediate early (CMV-EI) enhancer followed by a 1.3-kb DNA segment including the promoter, first exon and first intron of the chicken beta-actin gene, with the 3' splice junction sequence replaced by that of the rabbit hemoglobin beta gene. The prion protein coding sequence is followed by the rabbit beta-globin polyadenylation signal.