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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
基因编辑小鼠
Igk
tm1(Igk564)Tik
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基础信息
表型特征
文献报道
一个带有floxed Neo抗性基因的序列,以及来自自体免疫SWRxNZB小鼠杂交瘤产生的564 VkappaJkappa5区域,替换了包括整个J kappa区域的DNA一段。雄性嵌合体小鼠与C57BL/6雌性杂交。这些小鼠的后代与表达Cre的转基因小鼠杂交,以剔除Neo抗性基因 cassette。(参考文献J:113555)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
3687307
129S4/SvJae
Targeted
Insertion, Intergenic deletion
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--
--
13
Phenotypes
Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes
References Literature
Title
PMID
Journal
Year
IF
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