转基因包含来自M. m. molossinus衍生的封闭品系MSM肝脏基因组DNA的lambda噬菌体文库中1B-1克隆的15.5kbDNA片段,其中包含H2-T类非经典MHC I基因的5420bp编码外显子和内含子序列,5'端有3.8kb,3'端有6.3kb的非经典区段DNA。尽管在MSM小鼠中,内源基因仅在胸腺和肠道表达,但Northern blot分析显示转基因小鼠的这些器官(如胸腺、肠道、脾、淋巴结、骨髓和睾丸)中都存在转录本。用TL抗体的FACS分析确认了转基因小鼠胸腺、淋巴结和脾脏细胞中的蛋白表达。(引用文献:J:19193, J:113017)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C3H/He
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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