在loxP引导的诺姆西林筛选 cassette 替换了基因的编码外显子。通过 RT-PCR 分析了野生型(WT)和突变型(mutant)BM衍生巨噬细胞的 mRNA 表达。结果显示,突变型巨噬细胞中没有转录本,而野生型有。(来源:J:111778)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S1/Sv-Oca2+ Tyr+ Kitl+
Targeted
插入,基因内删除
--
1
3
52

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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