克里依赖的切除导致Klhl1基因去除了1号外显子。删除区域包含了富含CG的启动子区域、转录起始点、第一个内切点以及编码框架的起始部分。Klhl1as基因的整个转录序列和预测的启动子区域都缺失了。RT-PCR和Northern blot实验都证实了Klhl1转录本的缺失(来源:J:112937)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
129S1/Sv-Oca2+ Tyr+ Kitl+
Targeted
Insertion, Intergenic deletion
--
--
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
Show/Hide columns
Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
微信
信息比对
科研助手
使用教程
回到顶部