Metap2^tm1.2Ccr

Two loxP sites were inserted into the 5' UTR and the first intron via homologous recombination. A neomycin resistance gene flanked by two frt sequences was also introduced into the intron. Floxed mice with the neomycin resistance gene were crossed with Tg(ACTB-cre)2Mrt mice to remove the floxed exon 1. (J:111701)