设计了一种靶向载体,包含在21号外显子5'端的3个终止密码子和在21号外显子上游的neo cassette,后者通过Cre介导的重组被去除。实验结果显示,Nup96的独特序列消失,编码Nup98和Nup96共有6kDa多肽的20号外显子保持不变,从而保证了Nup98的持续表达。(来源:J:110907)
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cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count