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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
基因编辑小鼠
Rr165
tm2.1Crey
Alias:
Igk
tm2.1Crey
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基础信息
表型特征
文献报道
设计了一个靶向载体,目标是替换KI-KII元件(Rr163)的序列,其中KI部分由TCCACGCATGCTTGGA变更为TGTACGCTGCTGATGA,而KII部分从TCCTCTTCAGTGAGGAG更改为AGCTCTTCTAGACTGA。插入了LoxP位点,环绕着包含长J-C K生殖细胞转录起始子的4kb区域,该区域位于KI-KII元件的上游。后续通过Cre介导的重组,这个序列被删除了。(来源:J:110775)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
3653481
129P2/OlaHsd
Targeted
Insertion, Intergenic deletion
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--
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1
Phenotypes
Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes
References Literature
Title
PMID
Journal
Year
IF
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