设计了一个靶向载体,旨在替换KI-KII元件(Rr163)的8个和9个碱基,具体来说,KI序列从TCCACGCATGCTTGGA变更为TGTACGCTGCTGATGA,而KII序列从TCCTCTTCAGTGAGGAG更改为AGCTCTTCTAGACTGA。载体中插入了LoxP位点,环绕着包含长J-C K生殖细胞转录本启动子的4kb区域,该启动子位于KI-KII元件的上游,参考文献为J:110775。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
129P2/OlaHsd
Targeted
插入
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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