设计了一种向量,用于替换KI和KII位点的8个和9个碱基对(这两个是位于Igkv和Igkj基因片段间,参与Igk簇重组的 palindrome 序列)。KI位点的序列从TCCACGCATGCTTGGA变更为TGTACGCTGCTGATGA,而KII位点的序列从TCCTCTTCAGTGAGGAG更改为AGCTCTTCTAGACTGA。通过Cre介导的重组,删除了一个抗氨苄青霉素的耐药基因 cassette。(来源:J:31727)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
129P2/OlaHsd
Targeted
Insertion, Intergenic deletion
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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