这种突变是在对ENU处理的小鼠G3后代中,通过筛选对多种 Toll 样受体配体的响应发现的,它是一个T到A的转换,导致蛋白质Toll-IL-1受体(TIR)域(160-296位点)的异亮氨酸(I179)被天冬氨酸(Asparagine,N179)替换。(来源:J:86521, J:110094)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6
Chemically induced
单点
隐性
1
4
12

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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