J1 ES细胞被感染了携带有新霉素抗性基因的mp10病毒。筛选后,抗性ES细胞群被检测以确认单拷贝的病毒DNA存在。来自其中一个细胞系的鼠系被证明Cnbp基因的exon 1位置插入了变异。北标显示,异种和纯合子胚胎中该转录本水平显著降低,且在纯合子中完全缺失。(来源:J:81582)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S4/SvJae
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病毒插入
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1
1
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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