在通过同源重组插入到Hira基因的ES细胞系中,通过逆转录病毒插入了第二个loxP位点,位于Gp1bb和Cldn5基因之间。短暂的Cre表达导致Cldn5至Hira区域删除了大约150kb的基因片段。(来源:J:110378)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
129S7/SvEvBrd-Hprt1b-m2
Targeted
Intergenic deletion, Intragenic deletion
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4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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