在Es2el基因中插入了一个近端的loxP位点,目标是替换包含第四外显子的200bp片段。接着在Sept5基因中插入了第二个loxP位点,以替换2-4号外显子。经过转染,双同源靶向的胚胎干细胞经历了短暂的Cre表达,导致Es2el-Sept5区段的互换复制。(来源:J:67409)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
129S7/SvEvBrd-Hprt1b-m2
Targeted
重复
--
--
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
Show/Hide columns
Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
微信
信息比对
科研助手
使用教程
回到顶部