这个转基因载体包含了完整的成年大鼠Prkaa2基因,其中第45位的lysine被arginine替换(这个位点对ATP结合和水解至关重要),并且在5'端通过myc标签。它在肌肉Creatine Kinase启动子的调控下在骨骼和心肌中表达,而内源性Prkaa2的表达完全检测不到。(来源:J:110092)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(C57BL/6J x SJL/J)F1/J
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1
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46

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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