设计了一种靶向载体,用于替换第七外显子的一部分,替换区域包含耐药性诺卡因 cassette。被删除的序列编码了一段富含甘氨酸的区域。RT-PCR 和 Western blot 在突变体中分别未能检测到转录物和蛋白质。(来源:J:109077)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S2/SvPas
Targeted
插入,基因内删除
--
1
2
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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