设计了一个靶向载体,它在第3外显子的 sonic hedgehog加工域附近插入了loxP位点。随后是带有终止密码和FRT周围Neomycin抗性基因座的Myc标签。在终止密码后,Neomycin抗性基因座位于一个由flp重组酶表达的鼠的背景中被剔除。(来源:J:109101)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入
--
1
18
5

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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