Nrgn^tm1Sut

A targeting vector was designed to insert lacZ into exon 2 in frame such that a fusion protein would be expressed under the control of the endogenous promoter. The resulting protein consists of the first 30 residues of neurogranin followed by beta-gal sequence. The fusion protein does not contain the target of protein kinase C phosphorylation (Ser36) or residues required for binding to calmodulin. (J:109224)