人类雄性激素受体(Androgen Receptor, AR)从第31到第484位的氨基酸序列被插入到小鼠基因位点中。这个突变体在N端含有12个谷氨酰胺。短暂的Cre表达去除重组位点上的一个floxed neo标记。RT-PCR结果显示,突变体的转录本水平显著高于野生型。 Western blot结果显示,蛋白质水平也有所增加。(来源:J:108849)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S1/Sv-Oca2+ Tyr+ Kitl+
Targeted
插入
--
1
11
6

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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