在通过CAG-TBD-CRE-TBD转基因构建电转导入Runx1tm1Medv胚胎干细胞后,表达出Tamoxifen依赖的Cre重组酶,导致之前插入的Engrailed2-SA-lacZ序列被剔除,剩下位于基因5'UTR内的单个LoxP位点。肺和胸腺的Northern blot结果显示主要剪接异构体的正常表达。(来源:J:106769)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入,基因内删除
--
1
8
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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