可变的生殖细胞克隆Cre表达打乱了携带删除了第2号外显子的靶向等位基因,导致一些生殖腺细胞中去除了第2号外显子,而非预期的通过Camk2a-cre转基因对靶等位基因在特定组织中的特异性打乱。(来源:J:104338)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
基因内删除
--
1
1
7

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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