将含有人类IGFBP1基因cDNA的9.2kb转基因,通过小鼠α-fetoprotein调控序列,注入了C57BL/6 x CBA F1胚胎的卵母细胞核。建立了4个杂交品系(2、3、4、16)。品系2内含有4个转基因拷贝,主要在胎肝和卵黄囊中表达,而在肠道上皮细胞和脑星形胶质细胞中的表达水平较低。(来源:J:108414)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(C57BL/6 x CBA)F1
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1
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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