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中文
在一种靶向载体的帮助下，一个floxed neo被立即插入到了exon 2的上游。随后，这些ES细胞再次被靶向，以在一个新的靶向载体中将floxed neo插入到exon 2的exon 48下游。通过Cre重组酶的异染色质间重组，大部分定位区段丧失了，仅剩下起始编码段。最多，突变位点可能编码蛋白质的N端80个氨基酸。Northern blot没有检测到突变体的mRNA，Western blot确认了没有蛋白质表达。(来源：J:107376)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
