最前面的exon和第一个内含子的前230个碱基被rtTA编码区域替换。第一个exon编码该定位点的氨基端外分泌域和第一个跨膜域。在rtTA cassette下游,插入了两个loxP位点,使得转录激活蛋白受内源性启动子控制。与在生殖细胞中表达cre重组酶的 mice杂交移除去了含floxed neo的标记。(来源:J:58698)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入
--
1
6
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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