在内皮1插入了一个floxed PgkNeo cassette,同时在exon 5的3'非编码区也插入了第三个loxP位点。随后通过Cre介导的重组,从基因正确靶向的鼠中去除了2到5号外显子。北半球印迹分析在突变的心脏和肌肉样本中未检测到转录本(来源:J:106760)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S1/Sv-Oca2+ Tyr+ Kitl+
Targeted
基因内删除
--
1
5
7

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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