一个betagalactosidase-neo cassette替换了exon 3的剪接起始点,并包含了大部分内含子3。lacZ基因被插入到了外源性域的第三个EGF重复序列中,且与氨基酸118成框架。RT-PCR检测到了两个低水平表达的微小转录本,这些是由插入序列周围的替代剪接产生的。(来源:J:105278)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S1/Sv-Oca2+ Tyr+ Kitl+
Targeted
插入,基因内删除
--
1
3
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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