Zap70^mrtle

这种表型突变是在ENU诱变筛选中发现的，涉及第1601位点上的一个T到C转换，导致蛋白质（W504R）第504位的色氨酸被arginine替换，该蛋白质位于激酶域。在纯合突变和杂合突变的胸腺细胞中，该蛋白的水平分别约为野生型细胞的25%和50%。 (Source: The phenotypic mutation refers to a T-to-C change at position 1601, resulting in a W504R change in the protein, located in the kinase domain, with homozygous and heterozygous mutant thymocytes showing protein levels approximately 25% and 50% compared to wild-type ones.)