设计了一种靶向载体,用于将人类isoformRET51插入,其中1063-1072位点替换为RET9的1063-1072序列。这产生了类似于Rettm2(RET)Jmi的等位基因,但RET51的C端有RET9中不存在的Y1096。内源性转录在突变体中未检测到,但检测到了插入的人类RET9序列转录本。(参考文献:J:105047)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入
--
1
23
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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