设计了一种靶向载体,用于将人类isoformRET51插入,其中1063-1072位点替换为RET9的1063-1072序列。这产生了类似于Rettm2(RET)Jmi的等位基因,但RET51的C端有RET9中不存在的Y1096。内源性转录在突变体中未检测到,但检测到了插入的人类RET9序列转录本。(参考文献:J:105047)
Basic Information
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count