包含lacZ基因和RSV-neomycin抗性 cassette的靶向载体替换了前四个外显子的大部分蛋白质编码序列。 Western blot分析并未在纯合突变小鼠的海马组织中检测到蛋白质(来源:J:61471)
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A targeting vector containing a lacZ gene and an RSV-neomycin resistance cassette replaced most of the protein coding sequence in the first four exons. Western blot analysis did not detect protein in hippocampi from homozygous mutant mice. (J:61471)